Translin-associated factor X

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.^[5][6]

TSNAX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PJA, 3QB5
Identifiers
Aliases	TSNAX, TRAX, translin-associated factor X, translin associated factor X, C3PO
External IDs	OMIM: 602964; MGI: 1855672; HomoloGene: 4374; GeneCards: TSNAX; OMA:TSNAX - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.2 Start 231,528,541 bp[1] End 231,566,524 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E2|8 73.1 cM Start 125,739,736 bp[2] End 125,760,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus parietal pleura secondary oocyte buccal mucosa cell islet of Langerhans Skeletal muscle tissue of rectus abdominis visceral pleura germinal epithelium Skeletal muscle tissue of biceps brachii monocyte Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell Ileal epithelium neural layer of retina entorhinal cortex temporal muscle perirhinal cortex muscle of thigh prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding metal ion binding RNA binding single-stranded DNA binding endoribonuclease activity A2A adenosine receptor binding protein-containing complex binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol Golgi apparatus nucleus Biological process multicellular organism development cell differentiation spermatogenesis protein transport production of siRNA involved in RNA interference RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7257 53424 Ensembl ENSG00000116918 ENSMUSG00000056820 UniProt Q99598 Q9QZE7 RefSeq (mRNA) NM_005999 NM_016909 RefSeq (protein) NP_005990 NP_058605 Location (UCSC) Chr 1: 231.53 – 231.57 Mb Chr 8: 125.74 – 125.76 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.^[6] Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).^[7]

Interactions

TSNAX has been shown to interact with C1D.^[8]