UBE2G2

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.^[5][6][7]

UBE2G2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CYX, 2KLY, 2LXP, 3H8K, 4LAD
Identifiers
Aliases	UBE2G2, UBC7, ubiquitin conjugating enzyme E2 G2
External IDs	OMIM: 603124; MGI: 1343188; HomoloGene: 6599; GeneCards: UBE2G2; OMA:UBE2G2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 44,768,580 bp[1] End 44,801,826 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 77,458,109 bp[2] End 77,481,827 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii middle frontal gyrus internal globus pallidus body of pancreas paraflocculus of cerebellum epithelium of colon right coronary artery gastrocnemius muscle endothelial cell muscle layer of sigmoid colon Top expressed in otic placode otic vesicle muscle of thigh saccule soleus muscle masseter muscle interventricular septum esophagus lip ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity identical protein binding ubiquitin-protein transferase activity Cellular component endoplasmic reticulum cytosol Biological process ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination protein N-linked glycosylation via asparagine ubiquitin-dependent ERAD pathway cellular response to interferon-beta negative regulation of retrograde protein transport, ER to cytosol protein ubiquitination protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7327 22213 Ensembl ENSG00000184787 ENSMUSG00000009293 UniProt P60604 P60605 RefSeq (mRNA) NM_182688 NM_001202489 NM_003343 NM_019803 RefSeq (protein) NP_001189418 NP_003334 NP_872630 NP_062777 Location (UCSC) Chr 21: 44.77 – 44.8 Mb Chr 10: 77.46 – 77.48 Mb PubMed search [3] [4]
Wikidata
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7] Ube2g2 is known to interact with a variety of other proteins, including ubiquitin, the AMFR (E3 gp78), and the SYVN1 (Hrd1 RING).