USP14

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.^[5][6]

USP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AYN, 2AYO
Identifiers
Aliases	USP14, TGT, ubiquitin specific peptidase 14, Ubp6
External IDs	OMIM: 607274; MGI: 1928898; HomoloGene: 3780; GeneCards: USP14; OMA:USP14 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 158,383 bp[1] End 214,629 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A1|18 4.91 cM Start 9,993,066 bp[2] End 10,045,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibialis anterior muscle deltoid muscle pons thoracic diaphragm trabecular bone trigeminal ganglion lateral nuclear group of thalamus skin of hip spinal ganglia Top expressed in tail of embryo dorsomedial hypothalamic nucleus ventromedial nucleus dentate gyrus of hippocampal formation granule cell epiblast lateral septal nucleus mammillary body lateral hypothalamus superior frontal gyrus maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity proteasome binding peptidase activity protein binding thiol-dependent deubiquitinase cysteine-type endopeptidase activity endopeptidase inhibitor activity hydrolase activity tRNA guanylyltransferase activity Cellular component membrane plasma membrane synapse cell surface proteasome complex extracellular exosome cytoplasm cytosol cytoplasmic vesicle nucleus Biological process regulation of proteasomal protein catabolic process regulation of chemotaxis ubiquitin-dependent protein catabolic process proteolysis negative regulation of ER-associated ubiquitin-dependent protein catabolic process chemical synaptic transmission negative regulation of endopeptidase activity protein deubiquitination immune system process innate immune response tRNA 5'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9097 59025 Ensembl ENSG00000101557 ENSMUSG00000047879 UniProt P54578 Q9JMA1 RefSeq (mRNA) NM_005151 NM_001037334 NM_001038589 NM_021522 NM_001360884 RefSeq (protein) NP_001032411 NP_005142 NP_001033678 NP_067497 NP_001347813 Location (UCSC) Chr 18: 0.16 – 0.21 Mb Chr 18: 9.99 – 10.05 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

USP14 has been shown to interact with CXCR4.^[7]