USP5

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.^[5][6][7]

USP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DAG, 2DAK, 2G43, 2G45, 3IHP
Identifiers
Aliases	USP5, ISOT, ubiquitin specific peptidase 5
External IDs	OMIM: 601447; MGI: 1347343; HomoloGene: 55758; GeneCards: USP5; OMA:USP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,852,128 bp[1] End 6,866,632 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,791,982 bp[2] End 124,806,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex left testis right testis right frontal lobe right adrenal gland right adrenal cortex Brodmann area 9 left adrenal gland lateral nuclear group of thalamus gastrocnemius muscle Top expressed in spermatocyte dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex perirhinal cortex entorhinal cortex ventricular zone otic vesicle lip medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activity zinc ion binding ubiquitin binding protein binding hydrolase activity metal ion binding thiol-dependent deubiquitinase Cellular component lysosome cytosol Biological process protein K48-linked deubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process proteolysis protein deubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8078 22225 Ensembl ENSG00000111667 ENSMUSG00000038429 UniProt P45974 P56399 RefSeq (mRNA) NM_001098536 NM_003481 NM_013700 NM_001326594 RefSeq (protein) NP_001092006 NP_003472 NP_001369517 NP_001369518 NP_001369519 NP_001369520 NP_001313523 NP_038728 Location (UCSC) Chr 12: 6.85 – 6.87 Mb Chr 6: 124.79 – 124.81 Mb PubMed search [3] [4]
Wikidata
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Interactions

USP5 has been shown to interact with TADA3L.^[8]