V-erbA-related gene

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.^[5] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.^[6]

NR2F6
Identifiers
Aliases	NR2F6, EAR-2, EAR2, ERBAL2, nuclear receptor subfamily 2 group F member 6
External IDs	OMIM: 132880; MGI: 1352453; HomoloGene: 7706; GeneCards: NR2F6; OMA:NR2F6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,231,883 bp[1] End 17,245,919 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.43 cM Start 71,826,767 bp[2] End 71,834,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of transverse colon nasal epithelium jejunal mucosa palpebral conjunctiva right lobe of liver mucosa of sigmoid colon apex of heart corpus epididymis olfactory zone of nasal mucosa Top expressed in right kidney Paneth cell proximal tubule left lobe of liver internal carotid artery external carotid artery choroid plexus of fourth ventricle cumulus cell somite transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding nuclear receptor activity DNA-binding transcription factor activity DNA binding protein binding steroid hormone receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process transcription, DNA-templated signal transduction detection of temperature stimulus involved in sensory perception of pain entrainment of circadian clock by photoperiod negative regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter neuron development regulation of transcription, DNA-templated intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2063 13864 Ensembl ENSG00000160113 ENSMUSG00000002393 UniProt P10588 P43136 RefSeq (mRNA) NM_005234 NM_010150 RefSeq (protein) NP_005225 NP_005225.2 NP_034280 Location (UCSC) Chr 19: 17.23 – 17.25 Mb Chr 8: 71.83 – 71.83 Mb PubMed search [3] [4]
Wikidata
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Function

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.^[7][8]

Interactions

V-erbA-related gene has been shown to interact with:

• COUP-TFII^[9]
• Thyroid hormone receptor beta^[7]