COUP-TFII

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.^[5][6] The COUP acronym stands for chicken ovalbumin upstream promoter.

NR2F2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CJW
Identifiers
Aliases	NR2F2, ARP1, CHTD4, COUPTFB, COUPTFII, NF-E3, NR2F1, SVP40, TFCOUP2, COUP-TFII, nuclear receptor subfamily 2 group F member 2, COUPTF2, ARP-1, SRXX5
External IDs	OMIM: 107773; MGI: 1352452; HomoloGene: 7628; GeneCards: NR2F2; OMA:NR2F2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.2 Start 96,325,938 bp[1] End 96,340,263 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 C|7 38.66 cM Start 70,001,692 bp[2] End 70,016,483 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urethra cardia spinal ganglia renal medulla trigeminal ganglion right ovary stromal cell of endometrium decidua seminal vesicula saphenous vein Top expressed in Gonadal ridge genital tubercle vas deferens gastrula stroma of kidney ascending aorta sciatic nerve anterior amygdaloid area epithelium of stomach aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding retinoic acid binding protein homodimerization activity transcription corepressor activity DNA-binding transcription factor activity zinc ion binding metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process trophoblast giant cell differentiation response to estradiol regulation of transcription, DNA-templated blood vessel morphogenesis negative regulation of cyclin-dependent protein serine/threonine kinase activity lipid metabolism regulation of transcription by RNA polymerase II placenta blood vessel development radial pattern formation neuron migration in utero embryonic development negative regulation of transcription by RNA polymerase II lymph vessel development transcription, DNA-templated negative regulation of endothelial cell migration limb development negative regulation of endothelial cell proliferation positive regulation of transcription, DNA-templated maternal placenta development fertilization forebrain development negative regulation of transcription, DNA-templated skeletal muscle tissue development signal transduction anterior/posterior pattern specification steroid hormone mediated signaling pathway intracellular receptor signaling pathway positive regulation of systemic arterial blood pressure Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7026 11819 Ensembl ENSG00000185551 ENSMUSG00000030551 UniProt P24468 P43135 RefSeq (mRNA) NM_021005 NM_001145155 NM_001145156 NM_001145157 NM_009697 NM_183261 RefSeq (protein) NP_001138627 NP_001138628 NP_001138629 NP_066285 NP_033827 NP_899084 Location (UCSC) Chr 15: 96.33 – 96.34 Mb Chr 7: 70 – 70.02 Mb PubMed search [3] [4]
Wikidata
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Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.^[7][8]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.^[9][10] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.^[11]

Structure and ligands

The structure of COUP-TF2 LBD is known. Retinoic acid, although not at physiological concentrations, activate this receptor.^[12]

Interactions

COUP-TFII has been shown to interact with:

• HDAC1^[13]
• Lck^[14]
• V-erbA-related gene.^[15]
• Nucleolin^[16]