VAMP4

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.^[5][6]

VAMP4
Identifiers
Aliases	VAMP4, VAMP-4, VAMP24, vesicle associated membrane protein 4
External IDs	OMIM: 606909; MGI: 1858730; HomoloGene: 37847; GeneCards: VAMP4; OMA:VAMP4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.3 Start 171,700,160 bp[1] End 171,742,074 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.1|1 70.29 cM Start 162,398,084 bp[2] End 162,426,653 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus dorsal motor nucleus of vagus nerve inferior olivary nucleus pons pars compacta lateral nuclear group of thalamus cerebellar vermis tibia Top expressed in gastrula supraoptic nucleus pituitary gland motor neuron decidua Epithelium of choroid plexus dorsomedial hypothalamic nucleus lateral septal nucleus islet of Langerhans paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding SNARE binding Cellular component integral component of membrane cell surface Golgi membrane endosome Golgi apparatus lysosome membrane trans-Golgi network membrane SNARE complex transport vesicle plasma membrane clathrin-coated vesicle membrane integral component of synaptic vesicle membrane synaptic vesicle Biological process endoplasmic reticulum to Golgi vesicle-mediated transport Golgi ribbon formation microtubule cytoskeleton organization vesicle-mediated transport SNARE complex assembly Golgi to plasma membrane protein transport exocytosis membrane organization synaptic vesicle to endosome fusion regulation of synaptic vesicle endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8674 53330 Ensembl ENSG00000117533 ENSMUSG00000026696 UniProt O75379 O70480 RefSeq (mRNA) NM_001185127 NM_003762 NM_201994 NM_016796 NM_001347125 NM_001356526 NM_001356527 RefSeq (protein) NP_001172056 NP_003753 NP_001334054 NP_058076 NP_001343455 NP_001343456 Location (UCSC) Chr 1: 171.7 – 171.74 Mb Chr 1: 162.4 – 162.43 Mb PubMed search [3] [4]
Wikidata
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Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.^[6]

Interactions

VAMP4 has been shown to interact with AP1M1,^[7] STX6^[8] and STX16.^[8]