VPS18

Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.^[5][6][7]

VPS18
Identifiers
Aliases	VPS18, PEP3, CORVET/HOPS core subunit, VPS18 core subunit of CORVET and HOPS complexes
External IDs	OMIM: 608551; MGI: 2443626; HomoloGene: 13302; GeneCards: VPS18; OMA:VPS18 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 40,894,450 bp[1] End 40,903,975 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,119,221 bp[2] End 119,128,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tendon of biceps brachii stromal cell of endometrium apex of heart tibialis anterior muscle blood muscle of thigh islet of Langerhans prefrontal cortex white blood cell Top expressed in ankle joint neural layer of retina granulocyte yolk sac stroma of bone marrow primary visual cortex superior frontal gyrus right kidney dentate gyrus of hippocampal formation granule cell muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity metal ion binding protein binding actin binding syntaxin binding Cellular component HOPS complex AP-3 adaptor complex endosome late endosome membrane late endosome membrane autophagosome lysosomal membrane early endosome actin filament CORVET complex lysosome cytoplasmic vesicle clathrin-coated vesicle presynapse glutamatergic synapse Biological process endosome to lysosome transport endosome organization autophagy protein transport viral entry into host cell intracellular protein transport lysosome organization vesicle-mediated transport vesicle docking involved in exocytosis regulation of SNARE complex assembly transport regulation of synaptic vesicle exocytosis vacuole organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57617 228545 Ensembl ENSG00000104142 ENSMUSG00000034216 UniProt Q9P253 Q8R307 RefSeq (mRNA) NM_020857 NM_172269 RefSeq (protein) NP_065908 NP_065908.1 NP_758473 Location (UCSC) Chr 15: 40.89 – 40.9 Mb Chr 2: 119.12 – 119.13 Mb PubMed search [3] [4]
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[7]

Interactions

VPS18 has been shown to interact with VPS11^[8] and STX7.^[8]