VPS4B

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.^[5][6]

VPS4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WR0, 1XWI, 2CPT, 2JQH, 2JQK, 4U7Y
Identifiers
Aliases	VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
External IDs	OMIM: 609983; MGI: 1100499; HomoloGene: 37976; GeneCards: VPS4B; OMA:VPS4B - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.33 Start 63,389,190 bp[1] End 63,422,483 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.1 Start 106,691,801 bp[2] End 106,724,458 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell amniotic fluid epithelium of nasopharynx secondary oocyte gingival epithelium mucosa of ileum oral cavity Achilles tendon palpebral conjunctiva hair follicle Top expressed in conjunctival fornix ciliary body Paneth cell lacrimal gland hair follicle primitive streak iris vestibular sensory epithelium medullary collecting duct ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein homodimerization activity ATPase activity protein C-terminus binding protein binding identical protein binding hydrolase activity ATP binding Cellular component cytoplasm cytosol endosome centrosome spindle pole membrane late endosome membrane Flemming body endosome membrane extracellular exosome nucleus Biological process late endosomal microautophagy regulation of centrosome duplication protein depolymerization viral budding via host ESCRT complex viral life cycle nucleus organization cholesterol transport negative regulation of exosomal secretion multivesicular body assembly negative regulation of cell death regulation of mitotic spindle assembly endosome organization cell division positive regulation of centriole elongation endosomal transport potassium ion transport response to lipid ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway positive regulation of G2/M transition of mitotic cell cycle positive regulation of exosomal secretion septum digestion after cytokinesis mitotic metaphase plate congression endosome to lysosome transport via multivesicular body sorting pathway cell cycle ESCRT III complex disassembly macroautophagy transport positive regulation of viral process vacuole organization midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9525 20479 Ensembl ENSG00000119541 ENSMUSG00000009907 UniProt O75351 P46467 RefSeq (mRNA) NM_004869 NM_009190 RefSeq (protein) NP_004860 NP_004860.2 NP_033216 Location (UCSC) Chr 18: 63.39 – 63.42 Mb Chr 1: 106.69 – 106.72 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.

In humans, two paralogs of the yeast protein have been identified. They share a high degree of amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other (VPS4A) resides on chromosome 16.^[6]