WD repeat domain 18

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. ^[5]

WDR18
Identifiers
Aliases	WDR18, Ipi3, R32184_1, WD repeat domain 18
External IDs	MGI: 2158400; HomoloGene: 32573; GeneCards: WDR18; OMA:WDR18 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 984,332 bp[1] End 998,438 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,795,986 bp[2] End 79,806,037 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right lobe of liver mucosa of transverse colon apex of heart anterior pituitary right adrenal cortex right frontal lobe left adrenal gland muscle of thigh left adrenal cortex Top expressed in epiblast embryo embryo morula right kidney blastocyst hand spermatid spermatocyte neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus cytoplasm nucleoplasm nucleolus nuclear pre-replicative complex Rix1 complex Biological process multicellular organism development rRNA processing ribosomal large subunit assembly pre-replicative complex assembly involved in nuclear cell cycle DNA replication regulation of DNA-dependent DNA replication initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57418 216156 Ensembl ENSG00000065268 ENSMUSG00000035754 UniProt Q9BV38 Q4VBE8 RefSeq (mRNA) NM_024100 NM_001372085 NM_001372086 NM_175450 RefSeq (protein) NP_077005 NP_001359014 NP_001359015 NP_780659 Location (UCSC) Chr 19: 0.98 – 1 Mb Chr 10: 79.8 – 79.81 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP1, TEX10 called the rixosome which is involved in RNA degradation.^[6][7] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.^[8]