WHSC2

Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.^[5][6]

NELFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5L3X
Identifiers
Aliases	NELFA, NELF-A, WHSC2, P/OKcl.15, negative elongation factor complex member A
External IDs	OMIM: 606026; MGI: 1346098; HomoloGene: 68478; GeneCards: NELFA; OMA:NELFA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 1,982,717 bp[1] End 2,041,903 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,055,260 bp[2] End 34,093,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right uterine tube right hemisphere of cerebellum mucosa of transverse colon right testis left testis left ovary skin of leg right ovary Top expressed in secondary oocyte zygote primary oocyte tail of embryo genital tubercle epiblast neural tube embryo ventricular zone embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleoplasm cytosol nuclear body NELF complex Biological process multicellular organism development transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7469 24116 Ensembl ENSG00000185049 ENSMUSG00000029111 UniProt Q9H3P2 Q8BG30 RefSeq (mRNA) NM_005663 NM_011914 RefSeq (protein) NP_005654 NP_036044 Location (UCSC) Chr 4: 1.98 – 2.04 Mb Chr 5: 34.06 – 34.09 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.^[6] WHSC2 encodes the NELF-A subunit of the NELF complex.^[7]

Interactions

WHSC2 has been shown to interact with RDBP.^[7]