RDBP

Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.^[5]

NELFE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5P, 2BZ2, 2JX2
Identifiers
Aliases	NELFE, D6S45, NELF-E, RD, RDBP, RDP, negative elongation factor complex member E
External IDs	OMIM: 154040; MGI: 102744; HomoloGene: 134736; GeneCards: NELFE; OMA:NELFE - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,952,087 bp[1] End 31,959,038 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.4 cM Start 35,069,367 bp[2] End 35,075,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right uterine tube olfactory zone of nasal mucosa pituitary gland anterior pituitary C1 segment left adrenal cortex ventricular zone right adrenal gland Top expressed in seminiferous tubule internal carotid artery spermatid external carotid artery spermatocyte ventricular zone hair follicle maxillary prominence mandibular prominence epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding protein binding chromatin binding RNA binding Cellular component nucleus nucleoplasm NELF complex plasma membrane nuclear body Biological process negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade positive regulation of viral transcription transcription by RNA polymerase II regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of histone H3-K4 methylation negative regulation of transcription by RNA polymerase II negative regulation of mRNA polyadenylation transcription elongation from RNA polymerase II promoter transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7936 27632 Ensembl ENSG00000229363 ENSG00000206357 ENSG00000231044 ENSG00000204356 ENSG00000206268 ENSG00000233801 ENSMUSG00000024369 UniProt P18615 P19426 RefSeq (mRNA) NM_002904 NM_001045863 NM_001045864 NM_138580 RefSeq (protein) NP_002895 NP_001039328 NP_001039329 NP_613046 Location (UCSC) Chr 6: 31.95 – 31.96 Mb Chr 17: 35.07 – 35.08 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6.^[5]

Interactions

RDBP has been shown to interact with:

• Cofactor of BRCA1,^[6][7]
• TH1L,^[8][6] and
• WHSC2.^[6]