WWP1

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.^[5][6][7]

WWP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ND7, 5HPS, 5HPT
Identifiers
Aliases	WWP1, AIP5, Tiul1, hSDRP1, WW domain containing E3 ubiquitin protein ligase 1
External IDs	OMIM: 602307; MGI: 1861728; HomoloGene: 21385; GeneCards: WWP1; OMA:WWP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 86,342,547 bp[1] End 86,478,420 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 19,608,303 bp[2] End 19,708,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii body of tongue corpus epididymis caput epididymis superior surface of tongue lactiferous duct tail of epididymis mucosa of pharynx vastus lateralis muscle Top expressed in stroma of bone marrow triceps brachii muscle extraocular muscle sternocleidomastoid muscle vastus lateralis muscle muscle of thigh ankle temporal muscle digastric muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component ubiquitin ligase complex cytosol plasma membrane extracellular exosome membrane nucleus cytoplasm Biological process viral entry into host cell central nervous system development ion transmembrane transport viral process negative regulation of transcription, DNA-templated protein ubiquitination signal transduction ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11059 107568 Ensembl ENSG00000123124 ENSMUSG00000041058 UniProt Q9H0M0 Q8BZZ3 RefSeq (mRNA) NM_007013 NM_001276292 NM_177327 NM_001355222 RefSeq (protein) NP_008944 NP_001263221 NP_796301 NP_001342151 Location (UCSC) Chr 8: 86.34 – 86.48 Mb Chr 4: 19.61 – 19.71 Mb PubMed search [3] [4]
Wikidata
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Function

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.^[7] In neurons, murine ortholog Wwp1 and its homolog Wwp2 control polarity acquisition, formation, and branching of axons, as well as migration of newly born nerve cells into the cortical plate.^[8]

Interactions

WWP1 has been shown to interact with:

• CPSF6,^[9]
• KLF2,^[10] and
• Reticulon 4^[11]