YWHAG

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.^[5][6]

YWHAG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E
Identifiers
Aliases	YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56
External IDs	OMIM: 605356; MGI: 108109; HomoloGene: 22725; GeneCards: YWHAG; OMA:YWHAG - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 76,326,799 bp[1] End 76,358,991 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 135,937,263 bp[2] End 135,963,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pons pars compacta Brodmann area 23 spinal ganglia superior vestibular nucleus pars reticulata middle temporal gyrus endothelial cell Brodmann area 46 Top expressed in CA3 field perirhinal cortex entorhinal cortex primary motor cortex dorsomedial hypothalamic nucleus dorsal tegmental nucleus anterior amygdaloid area ventral tegmental area subiculum ventromedial nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function insulin-like growth factor receptor binding protein domain specific binding receptor tyrosine kinase binding protein binding protein kinase C binding protein kinase C inhibitor activity RNA binding identical protein binding Cellular component cytoplasm cytosol membrane focal adhesion myelin sheath extracellular exosome cytoplasmic vesicle membrane mitochondrion vesicle synapse presynapse Biological process regulation of neuron differentiation protein targeting negative regulation of protein kinase activity regulation of synaptic plasticity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction G2/M transition of mitotic cell cycle cellular response to insulin stimulus membrane organization negative regulation of protein serine/threonine kinase activity ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7532 22628 Ensembl ENSG00000170027 ENSMUSG00000051391 UniProt P61981 P61982 RefSeq (mRNA) NM_012479 NM_018871 RefSeq (protein) NP_036611 NP_061359 Location (UCSC) Chr 7: 76.33 – 76.36 Mb Chr 5: 135.94 – 135.96 Mb PubMed search [3] [4]
Wikidata
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This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.^[7]

Interactions

YWHAG has been shown to interact with C-Raf,^[6][8][9] EPB41L3,^[8][10] KIF1C^[11] and Stratifin.^[12]