ZMYND11

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.^[5][6][7]

ZMYND11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NS5, 5HDA
Identifiers
Aliases	ZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDs	OMIM: 608668; MGI: 1913755; HomoloGene: 4828; GeneCards: ZMYND11; OMA:ZMYND11 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.3 Start 134,465 bp[1] End 254,637 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 9,734,869 bp[2] End 9,815,366 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve caput epididymis tail of epididymis corpus epididymis lactiferous duct inferior ganglion of vagus nerve corpus callosum superior vestibular nucleus postcentral gyrus Brodmann area 46 Top expressed in ciliary body retinal pigment epithelium iris barrel cortex conjunctival fornix ureter Region I of hippocampus proper substantia nigra Epithelium of choroid plexus medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding transcription coregulator activity metal ion binding protein binding transcription corepressor activity histone binding double-stranded DNA binding zinc ion binding methylated histone binding Cellular component nucleoplasm chromosome nucleus Biological process regulation of transcription, DNA-templated negative regulation of extrinsic apoptotic signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling transcription, DNA-templated negative regulation of JNK cascade cell cycle cell population proliferation viral process regulation of transcription elongation from RNA polymerase II promoter defense response to virus negative regulation of nucleic acid-templated transcription chromatin organization negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10771 66505 Ensembl ENSG00000015171 ENSMUSG00000021156 UniProt Q15326 Q8R5C8 RefSeq (mRNA) NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_006624 NM_212479 NM_001330057 NM_001199141 NM_144516 NM_001347470 NM_001347471 NM_001347472 NM_001347473 NM_001347474 NM_001347476 NM_001347477 NM_001347479 NM_001347480 NM_001347481 RefSeq (protein) NP_001189393 NP_001189394 NP_001189395 NP_001189396 NP_001189397 NP_001316986 NP_006615 NP_997644 NP_001357026 NP_001357027 NP_001357028 NP_001357029 NP_001357030 NP_001357031 NP_001357032 NP_001357033 NP_001357034 NP_001357035 NP_001357036 NP_001357037 NP_001357038 NP_001357039 NP_001357040 NP_001357041 NP_001357042 NP_001357043 NP_001357044 NP_001357045 NP_001357046 NP_001357047 NP_001357048 NP_001357049 NP_001357050 NP_001357051 NP_001357052 NP_001357053 NP_001186070 NP_001334399 NP_001334400 NP_001334401 NP_001334402 NP_001334403 NP_001334405 NP_001334406 NP_001334408 NP_001334409 NP_001334410 NP_653099 Location (UCSC) Chr 10: 0.13 – 0.25 Mb Chr 13: 9.73 – 9.82 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

Interactions

ZMYND11 has been shown to interact with:

• BMPR1A,^[8]
• C11orf30,^[9]
• ETS2,^[10] and
• TAB1.^[8]
• H3.3K36me3^[11]