ZNF598

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.^[5]

ZNF598
Identifiers
Aliases	ZNF598, zinc finger protein 598, HEL2, zinc finger protein 598, E3 ubiquitin ligase
External IDs	OMIM: 617508; MGI: 2670965; HomoloGene: 5672; GeneCards: ZNF598; OMA:ZNF598 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,997,654 bp[1] End 2,009,821 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,888,661 bp[2] End 24,900,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg body of pancreas skin of abdomen sural nerve minor salivary glands granulocyte anterior pituitary right hemisphere of cerebellum right lobe of liver mucosa of transverse colon Top expressed in gallbladder superior surface of tongue lactiferous gland zygote crypt of lieberkuhn of small intestine Ileal epithelium choroid plexus of fourth ventricle secondary oocyte primary oocyte lip More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 90850 213753 Ensembl ENSG00000167962 ENSMUSG00000041130 UniProt Q86UK7 Q80YR4 RefSeq (mRNA) NM_178167 NM_001405664 NM_001405665 NM_183149 NM_001348231 RefSeq (protein) NP_835461 NP_898972 NP_001335160 Location (UCSC) Chr 16: 2 – 2.01 Mb Chr 17: 24.89 – 24.9 Mb PubMed search [3] [4]
Wikidata
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Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex.^[6] The complex is thought to function as a translation repressor in embryonic development. ZNF598 and its yeast homologue Hel2 are ubiquitin ligases that ubiquitinate the 40S ribosomal subunit during ribosome-associated protein quality control.^{[7][8][9][10]}