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ALD-52

Chemical compound From Wikipedia, the free encyclopedia

ALD-52
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ALD-52, also known as 1-acetyl-LSD (1A-LSD), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[3][4] It has been reported to produce similar psychoactive effects as LSD, but its pharmacological effects on humans are poorly understood.[3][4]

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The drug is assumed to act as a prodrug to LSD in humans, and this has been substantiated in vitro.[4][5]

ALD-52 was initially synthesized in 1957 by Albert Hofmann.[6] The purported first confirmed detection of the substance on the illicit market occurred in April 2016.[4][7]

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Use and effects

In Entry 26 of his compendium TiHKAL, which discussed LSD, chemist Alexander Shulgin touched briefly on the subject of ALD-52. His comments there are vague, second-hand accounts saying doses in the 50–175 μg range have resulted in various conclusions. One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. One subject claimed it was more effective in increasing blood pressure, and another could not tell them apart.[3]

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Interactions

Pharmacology

In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.[8]

Society and culture

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Austria

ALD-52 is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD.

Denmark

ALD-52 is not listed as an illegal substance in Denmark as of April 2019, and its chemical class 'lysergamide' is not banned under the Analogue Act (some LSD analogues are, however, prohibited).[9]

Finland

ALD-52 is labeled a controlled psychoactive substance in Finland as of 2014.[10]

Germany

ALD-52 is controlled under the NpSG as of July 18, 2019.[11][12] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.[13]

Latvia

ALD-52 is illegal in Latvia. Although it is not officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.[14]

Romania

ALD-52 is illegal to produce or sell in Romania. It is not included directly in the list of controlled substances, but it is included in an analogue act. However, it is not, as of yet, classified as illegal to use.

Singapore

ALD-52 is a class A controlled drug, and is illegal to traffic, manufacture, import, export, possess, or consume in Singapore as of December 1, 2019, punishable with a minimum of five years' imprisonment and five strokes of the cane.[15]

Switzerland

Since March 2018, ALD-52 is illegal in Switzerland and has been put in the RS 812.121.11.

United Kingdom

On June 10, 2014, the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that ALD-52 be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.[16] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.

United States

ALD-52 is unscheduled in the United States. It may be considered an analogue of LSD, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or scientific use could be prosecuted as crimes under the Federal Analogue Act however could be legal for medical and research uses like a research chemical.[17]

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See also

References

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