ACAD10

Acyl-CoA dehydrogenase family, member 10 is a protein that in humans is encoded by the ACAD10 gene.^[5]

ACAD10
Identifiers
Aliases	ACAD10, acyl-CoA dehydrogenase family member 10
External IDs	OMIM: 611181; MGI: 1919235; HomoloGene: 49825; GeneCards: ACAD10; OMA:ACAD10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.12 Start 111,686,053 bp[1] End 111,757,107 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 121,759,089 bp[2] End 121,798,577 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lobe of liver parotid gland mucosa of transverse colon human kidney right adrenal gland right adrenal cortex right uterine tube body of pancreas left adrenal cortex Top expressed in proximal tubule right kidney human kidney trigeminal ganglion liver white adipose tissue urinary bladder muscle of thigh adrenal gland spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on the CH-CH group of donors oxidoreductase activity hydrolase activity acyl-CoA dehydrogenase activity flavin adenine dinucleotide binding Cellular component mitochondrial matrix mitochondrion Biological process fatty acid beta-oxidation metabolism fatty acid beta-oxidation using acyl-CoA dehydrogenase Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80724 71985 Ensembl ENSG00000111271 ENSMUSG00000029456 UniProt Q6JQN1 Q8K370 RefSeq (mRNA) NM_025247 NM_001136538 NM_001136542 NM_028037 RefSeq (protein) NP_001130010 NP_079523 NP_082313 Location (UCSC) Chr 12: 111.69 – 111.76 Mb Chr 5: 121.76 – 121.8 Mb PubMed search [3] [4]
Wikidata
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Structure

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[5]

Clinical significance

In Pima people, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and American Indians.^[6]

Interactions

Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, APP, MAS1, CD79A, BSG, and Ubiquitin C.^[7]