ACAT2

Not to be confused with Acyl-CoA:cholesterol acyltransferase or Acetyl-CoA C-acyltransferase.

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene^[5]

ACAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WL4, 1WL5
Identifiers
Aliases	ACAT2, acetyl-CoA acetyltransferase 2
External IDs	OMIM: 100678; MGI: 87871; HomoloGene: 55855; GeneCards: ACAT2; OMA:ACAT2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,762,045 bp[1] End 159,779,112 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.73 cM Start 13,161,777 bp[2] End 13,179,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence Pons right lobe of liver skin of thigh C1 segment mucosa of transverse colon mucosa of esophagus islet of Langerhans prefrontal cortex Top expressed in condyle fossa internal carotid artery external carotid artery superior cervical ganglion motor neuron cumulus cell medial ganglionic eminence maxillary prominence mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity acyltransferase activity catalytic activity protein binding acyltransferase activity, transferring groups other than amino-acyl groups acetyl-CoA C-acetyltransferase activity acetyl-CoA C-acyltransferase activity Cellular component cytoplasm nucleolus extracellular exosome nucleus mitochondrion cytosol Biological process metabolism lipid metabolism fatty acid beta-oxidation cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 39 110460 Ensembl ENSG00000120437 ENSMUSG00000023832 UniProt Q9BWD1 Q8CAY6 RefSeq (mRNA) NM_005891 NM_001303253 NM_009338 RefSeq (protein) NP_001290182 NP_005882 NP_033364 Location (UCSC) Chr 6: 159.76 – 159.78 Mb Chr 17: 13.16 – 13.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase enzyme.

Gene

This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.^[5]