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ADB-CHMINACA
Chemical compound From Wikipedia, the free encyclopedia
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ADB-CHMINACA (also known as ADMB-CHMINACA[3] and MAB-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of Ki = 0.289 nM and was originally developed by Pfizer in 2009 as an analgesic medication.[4][5] It was identified in cannabinoid blends in Japan in early 2015.[6]
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Side effects
There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.[7][8][9][10][11][12][13][14]
Legal status
In the United States, ADB-CHMINACA is a Schedule I controlled substance.[15] Prior to its listing at the federal level in 2018, Louisiana placed ADB-CHMINACA on its Schedule I list by emergency scheduling in 2014.[16]
Sweden's public health agency suggested to classify ADB-CHMINACA as hazardous substance on November 10, 2014.[17]
ADB-CHMINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[18]
ADB-CHMINACA is illegal in Switzerland as of December 2015.[19]
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Metabolism
Ten ADB-CHMINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Most transformations occurred at the cyclohexylmethyl tail of the compound.[20]
See also
References
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