ANAPC5

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.^[5][6]

ANAPC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC5, APC5, anaphase promoting complex subunit 5
External IDs	OMIM: 606948; MGI: 1929722; HomoloGene: 41118; GeneCards: ANAPC5; OMA:ANAPC5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 121,308,245 bp[1] End 121,399,896 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,925,522 bp[2] End 122,959,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas bronchial epithelial cell tibia canal of the cervix skin of hip body of uterus corpus callosum tibial nerve right ovary Top expressed in fossa condyle internal carotid artery external carotid artery fetal liver hematopoietic progenitor cell Paneth cell superior cervical ganglion hair follicle trigeminal ganglion vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding ubiquitin protein ligase activity Cellular component nucleoplasm cytosol nucleus anaphase-promoting complex Biological process cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division positive regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51433 59008 Ensembl ENSG00000089053 ENSMUSG00000029472 UniProt Q9UJX4 Q8BTZ4 RefSeq (mRNA) NM_001137559 NM_016237 NM_001330489 NM_001042491 NM_001289517 NM_001289518 NM_001289519 NM_001289520 NM_021505 RefSeq (protein) NP_001131031 NP_001317418 NP_057321 NP_001035956 NP_001276446 NP_001276447 NP_001276448 NP_001276449 NP_067480 Location (UCSC) Chr 12: 121.31 – 121.4 Mb Chr 5: 122.93 – 122.96 Mb PubMed search [3] [4]
Wikidata
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The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM]^[6]

Interactions

ANAPC5 has been shown to interact with ANAPC1,^[7][8] ANAPC4,^[7] CDC27^[7][9][10] and PABPC1.^[9]