ANAPC4

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.^[5][6]

ANAPC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5BPW, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC4, APC4, anaphase promoting complex subunit 4
External IDs	OMIM: 606947; MGI: 1098673; HomoloGene: 40873; GeneCards: ANAPC4; OMA:ANAPC4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,377,263 bp[1] End 25,418,498 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 28.81 cM Start 52,991,354 bp[2] End 53,025,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube endometrium tendon of biceps brachii germinal epithelium bronchial epithelial cell parietal pleura visceral pleura Brodmann area 23 thymus tibia Top expressed in primary oocyte neural layer of retina superior cervical ganglion ventricular zone pituitary gland vas deferens ganglionic eminence limb bud fossa condyle More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein phosphatase binding protein binding ubiquitin protein ligase activity Cellular component anaphase-promoting complex cytosol nucleus nucleoplasm nuclear periphery Biological process anaphase-promoting complex-dependent catabolic process regulation of mitotic metaphase/anaphase transition cell division protein K11-linked ubiquitination cell cycle protein ubiquitination positive regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29945 52206 Ensembl ENSG00000053900 ENSMUSG00000029176 UniProt Q9UJX5 Q91W96 RefSeq (mRNA) NM_001286756 NM_013367 NM_024213 RefSeq (protein) NP_001273685 NP_037499 NP_077175 Location (UCSC) Chr 4: 25.38 – 25.42 Mb Chr 5: 52.99 – 53.03 Mb PubMed search [3] [4]
Wikidata
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A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.^[6]

Interactions

ANAPC4 has been shown to interact with ANAPC1,^[7][8] ANAPC5,^[7] CDC27^[7][9] and ANAPC7.^[7]