ANAPC7

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.^[5] Multiple transcript variants encoding different isoforms have been found for this gene.

ANAPC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FFL, 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	ANAPC7, APC7, anaphase promoting complex subunit 7, FERBON
External IDs	OMIM: 606949; MGI: 1929711; HomoloGene: 10512; GeneCards: ANAPC7; OMA:ANAPC7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,372,900 bp[1] End 110,403,730 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 122,559,756 bp[2] End 122,582,975 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of esophagus skin of arm right testis left testis gonad cerebellar hemisphere right hemisphere of cerebellum right uterine tube vagina Top expressed in otic vesicle saccule otic placode interventricular septum external carotid artery internal carotid artery tunica media of zone of aorta medullary collecting duct epithelium of lens trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding protein binding Cellular component nucleoplasm cytosol anaphase-promoting complex nucleus Biological process cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51434 56317 Ensembl ENSG00000196510 ENSMUSG00000029466 UniProt Q9UJX3 Q9WVM3 RefSeq (mRNA) NM_001137664 NM_016238 NM_001385208 NM_001385209 NM_001385210 NM_001385211 NM_001385212 NM_019805 RefSeq (protein) NP_001131136 NP_057322 NP_057322.2 NP_062779 Location (UCSC) Chr 12: 110.37 – 110.4 Mb Chr 5: 122.56 – 122.58 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.^[5]

Interactions

ANAPC7 has been shown to interact with ANAPC1,^[6][7] ANAPC4,^[6] CDC27^[6][8] and CDC20.^[6][9]