ARHGAP5

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.^[5][6]

ARHGAP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE4, 2EE5
Identifiers
Aliases	ARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
External IDs	OMIM: 602680; MGI: 1332637; HomoloGene: 907; GeneCards: ARHGAP5; OMA:ARHGAP5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 32,076,114 bp[1] End 32,159,728 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C1|12 22.16 cM Start 52,550,755 bp[2] End 52,618,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone endothelial cell Epithelium of choroid plexus epithelium of colon Brodmann area 23 corpus callosum retinal pigment epithelium buccal mucosa cell corpus epididymis Top expressed in lobe of cerebellum ciliary body retinal pigment epithelium cerebellar vermis spermatocyte iris Rostral migratory stream vestibular sensory epithelium parotid gland deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP binding SH2 domain binding protein binding GTPase activator activity GTPase activity Cellular component endoplasmic reticulum membrane cytoplasm cytosol plasma membrane Biological process cell adhesion regulation of small GTPase mediated signal transduction Rho protein signal transduction signal transduction mammary gland development positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 394 11855 Ensembl ENSG00000100852 ENSMUSG00000035133 UniProt Q13017 P97393 RefSeq (mRNA) NM_001030055 NM_001173 NM_009706 RefSeq (protein) NP_001025226 NP_001164 NP_033836 Location (UCSC) Chr 14: 32.08 – 32.16 Mb Chr 12: 52.55 – 52.62 Mb PubMed search [3] [4]
Wikidata
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Function

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

ARHGAP5 has been shown to interact with Rnd1,^[7] Rnd2,^[7] Rnd3^[7] and RHOA.^[7]