Rnd2

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.^[5] It is encoded by the gene RND2.^[6]

RND2
Identifiers
Aliases	RND2, ARHN, RHO7, RhoN, Rnd2, Rho family GTPase 2
External IDs	OMIM: 601555; MGI: 1338755; HomoloGene: 21123; GeneCards: RND2; OMA:RND2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,025,231 bp[1] End 43,032,041 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,355,825 bp[2] End 101,362,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment internal globus pallidus hypothalamus substantia nigra superior vestibular nucleus nucleus accumbens pars reticulata left testis external globus pallidus right testis Top expressed in ganglionic eminence cerebellar cortex pons inferior colliculi medulla oblongata striatum of neuraxis superior frontal gyrus superior colliculus olfactory bulb dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity protein N-terminus binding protein kinase binding Cellular component early endosome acrosomal membrane membrane cytoplasmic vesicle intracellular anatomical structure cytoplasm plasma membrane cell cortex cell division site intracellular membrane-bounded organelle Biological process small GTPase mediated signal transduction positive regulation of collateral sprouting signal transduction actin filament organization Rho protein signal transduction regulation of cell shape regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization actin filament bundle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8153 11858 Ensembl ENSG00000108830 ENSMUSG00000001313 UniProt P52198 Q9QYM5 RefSeq (mRNA) NM_005440 NM_009708 RefSeq (protein) NP_005431 NP_033838 Location (UCSC) Chr 17: 43.03 – 43.03 Mb Chr 11: 101.36 – 101.36 Mb PubMed search [3] [4]
Wikidata
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Function

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]^[7]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.^[6]

Interactions

Rnd2 has been shown to interact with:

• ARHGAP5,^[8]
• RACGAP1,^[9] and
• UBXD5.^[10]