PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.^[5][6][7] PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC 3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.^[8]

PDE6D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KSG, 1KSH, 1KSJ, 3T5G, 3T5I, 4JHP, 4JV6, 4JV8, 4JVB, 4JVF, 5E8F, 5E80, 5F2U
Identifiers
Aliases	PDE6D, JBTS22, PDED, phosphodiesterase 6D
External IDs	OMIM: 602676; MGI: 1270843; HomoloGene: 1954; GeneCards: PDE6D; OMA:PDE6D - orthologs
EC number	3.1.4.35
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,732,433 bp[1] End 231,786,272 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 86,470,716 bp[2] End 86,510,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis C1 segment ventricular zone ganglionic eminence caudate nucleus Amygdala putamen prefrontal cortex cingulate gyrus Top expressed in neural layer of retina olfactory epithelium zygote tail of embryo primary oocyte medial ganglionic eminence seminiferous tubule sternocleidomastoid muscle genital tubercle endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase inhibitor activity protein binding 3',5'-cyclic-nucleotide phosphodiesterase activity Cellular component cytoplasm cytosol cell projection cytoskeleton cytoplasmic vesicle membrane membrane cytoplasmic vesicle cilium Biological process negative regulation of GTPase activity response to stimulus visual perception sensory perception of light stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5147 18582 Ensembl ENSG00000156973 ENSMUSG00000026239 UniProt O43924 Q6IB24 O55057 RefSeq (mRNA) NM_001291018 NM_002601 NM_008801 NM_001360816 NM_001360817 RefSeq (protein) NP_001277947 NP_002592 NP_002592.1 NP_032827 NP_001347745 NP_001347746 Location (UCSC) Chr 2: 231.73 – 231.79 Mb Chr 1: 86.47 – 86.51 Mb PubMed search [3] [4]
Wikidata
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Interactions

PDE6D has been shown to interact with:

• ARL2^[9][10]
• HRAS^[10][11]
• RAP1A^[10][11]
• Retinitis pigmentosa GTPase regulator^[12]
• Rnd1^[10][11]