Biotin attachment domain

Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme.^[1] Lipoamide acyltransferases have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group.^[2] The lipoic acid cofactor is found in a variety of proteins.

Biotin/lipoyl attachment domain
Identifiers
Symbol	Biotin_lipoyl
Pfam	PF00364
InterPro	IPR000089
PROSITE	PDOC00168
SCOP2	1lab / SCOPe / SUPFAM
CDD	cd06663
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1dczA:55-122 1dd2A:55-122 1o78A:55-122 1k67B:81-155 2bdoA:81-155 1k69B:81-155 3bdoA:81-155 1bdo :81-155 1a6x :81-155 1y8pB:186-260 1y8nB:186-260 1fyc :186-260 1y8oB:186-260 1ghk :3-76 1ghj :3-76 1gjxA:4-76 1qjoA:207-278 1iyu :3-73 1iyv :3-73 1lac :3-76 1lab :3-76 1k8mA:65-138 1k8oA:65-138

Human proteins containing this domain

ACACA; ACACB; DBT; DLAT; DLST; DLSTP; MCCC1; PC; PCCA; PDHX;