CCR1

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[5]

CCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y5D
Identifiers
Aliases	CCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	OMIM: 601159; MGI: 104618; HomoloGene: 20344; GeneCards: CCR1; OMA:CCR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,201,711 bp[1] End 46,208,313 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 75.05 cM Start 123,762,161 bp[2] End 123,768,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte periodontal fiber buccal mucosa cell appendix spleen decidua bone marrow trabecular bone Top expressed in granulocyte stroma of bone marrow tibiofemoral joint blood ankle body of femur spleen ankle joint lumbar subsegment of spinal cord duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-C chemokine binding G protein-coupled receptor activity chemokine (C-C motif) ligand 5 binding signal transducer activity chemokine (C-C motif) ligand 7 binding protein binding chemokine receptor activity C-C chemokine receptor activity phosphatidylinositol phospholipase C activity chemokine binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane cytoplasm Biological process negative regulation of bone mineralization positive regulation of cell migration positive regulation of cytosolic calcium ion concentration chemokine-mediated signaling pathway cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of monocyte chemotaxis cellular calcium ion homeostasis positive regulation of osteoclast differentiation dendritic cell chemotaxis negative regulation of gene expression chemotaxis cell surface receptor signaling pathway cell adhesion response to wounding immune response positive regulation of ERK1 and ERK2 cascade inflammatory response calcium ion transport signal transduction exocytosis positive regulation of calcium ion transport G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1230 12768 Ensembl ENSG00000163823 ENSMUSG00000025804 UniProt P32246 P51675 RefSeq (mRNA) NM_001295 NM_009912 RefSeq (protein) NP_001286 NP_034042 Location (UCSC) Chr 3: 46.2 – 46.21 Mb Chr 9: 123.76 – 123.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

Function

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[6]

Interactions

CCR1 has been shown to interact with CCL5.^[7][8]