CEP68

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.^[5][6][7][8] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend on each other for centriole association, and both also require CEP250 for their function.^[9]

CEP68
Identifiers
Aliases	CEP68, KIAA0582, centrosomal protein 68
External IDs	OMIM: 616889; MGI: 2667663; HomoloGene: 65235; GeneCards: CEP68; OMA:CEP68 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 65,056,366 bp[1] End 65,087,004 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.1|11 12.92 cM Start 20,177,037 bp[2] End 20,199,429 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii glutes Skeletal muscle tissue of rectus abdominis skin of hip skin of thigh superficial temporal artery parietal pleura urethra nipple Top expressed in Rostral migratory stream digastric muscle extraocular muscle sternocleidomastoid muscle triceps brachii muscle soleus muscle temporal muscle abdominal wall vastus lateralis muscle myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein kinase binding protein binding Cellular component cell junction nucleus centrosome microtubule organizing center cytoskeleton cytoplasm cytosol Biological process protein localization to organelle centriole-centriole cohesion centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23177 216543 Ensembl ENSG00000011523 ENSMUSG00000044066 UniProt Q76N32 Q8C0D9 RefSeq (mRNA) NM_015147 NM_001319100 NM_001319101 NM_172260 RefSeq (protein) NP_001306029 NP_001306030 NP_055962 NP_758464 Location (UCSC) Chr 2: 65.06 – 65.09 Mb Chr 11: 20.18 – 20.2 Mb PubMed search [3] [4]
Wikidata
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