CHAF1A

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.^[5][6]

CHAF1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S4Z
Identifiers
Aliases	CHAF1A, CAF-1, CAF1, CAF1B, CAF1P150, P150, chromatin assembly factor 1 subunit A
External IDs	OMIM: 601246; MGI: 1351331; HomoloGene: 4003; GeneCards: CHAF1A; OMA:CHAF1A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,402,640 bp[1] End 4,445,018 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,347,439 bp[2] End 56,379,289 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sural nerve ventricular zone nipple embryo ganglionic eminence gingival epithelium pylorus amniotic fluid Skeletal muscle tissue of rectus abdominis Top expressed in primary oocyte secondary oocyte embryonic cell zygote bone marrow yolk sac epiblast tail of embryo otic vesicle testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding chromatin binding protein binding chromo shadow domain binding identical protein binding Cellular component CAF-1 complex nucleus protein-containing complex Biological process DNA replication cell cycle DNA repair cellular response to DNA damage stimulus DNA replication-dependent chromatin assembly nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10036 27221 Ensembl ENSG00000167670 ENSMUSG00000002835 UniProt Q13111 Q9QWF0 RefSeq (mRNA) NM_005483 NM_013733 RefSeq (protein) NP_005474 NP_038761 Location (UCSC) Chr 19: 4.4 – 4.45 Mb Chr 17: 56.35 – 56.38 Mb PubMed search [3] [4]
Wikidata
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Function

Chromatin assembly factor I (CAF-1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM]^[6]

Interactions

CHAF1A has been shown to interact with:

• ASF1A,^[7]
• ASF1B,^[7][8]
• BLM,^[9]
• CBX5,^[10][11] and
• MBD1.^[10]