CKAP5

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene.^[5][6][7] It is the homolog of the Xenopus protein XMAP215^[8] and is also known as ch-Tog.

CKAP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QMI, 4QMJ
Identifiers
Aliases	CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton associated protein 5
External IDs	OMIM: 611142; MGI: 1923036; HomoloGene: 8844; GeneCards: CKAP5; OMA:CKAP5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 46,743,048 bp[1] End 46,846,308 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 91,357,107 bp[2] End 91,451,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence oocyte right testis stromal cell of endometrium Achilles tendon left testis secondary oocyte prefrontal cortex cerebellar hemisphere Top expressed in tail of embryo genital tubercle ventricular zone gastrula ganglionic eminence cerebellar cortex maxillary prominence secondary oocyte mandibular prominence zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding microtubule plus-end binding Cellular component cytoplasm cytosol centrosome spindle pole membrane microtubule cytoskeleton gamma-tubulin complex microtubule organizing center microtubule plus-end cytoskeleton chromosome, centromeric region kinetochore chromosome spindle nucleolus plasma membrane protein-containing complex Biological process RNA transport establishment or maintenance of microtubule cytoskeleton polarity cell division spindle organization G2/M transition of mitotic cell cycle cell cycle sister chromatid cohesion centrosome cycle microtubule polymerization centrosome duplication ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9793 75786 Ensembl ENSG00000175216 ENSMUSG00000040549 UniProt Q14008 A2AGT5 RefSeq (mRNA) NM_014756 NM_001008938 NM_001165989 NM_029437 RefSeq (protein) NP_001008938 NP_055571 NP_001159461 NP_083713 Location (UCSC) Chr 11: 46.74 – 46.85 Mb Chr 2: 91.36 – 91.45 Mb PubMed search [3] [4]
Wikidata
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It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.^[9]

Interactions

CKAP5 has been shown to interact with TACC1.^[10][11]