COG4

Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.^[5][6]

COG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HR0
Identifiers
Aliases	COG4, CDG2J, COD1, component of oligomeric golgi complex 4, SWILS
External IDs	OMIM: 606976; MGI: 2142808; HomoloGene: 7155; GeneCards: COG4; OMA:COG4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 70,480,568 bp[1] End 70,523,560 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 57.76 cM Start 111,573,232 bp[2] End 111,608,859 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart muscle of thigh right testis granulocyte gastrocnemius muscle rectum left testis ventricular zone right adrenal gland Top expressed in interventricular septum spermatocyte spermatid internal carotid artery muscle of thigh external carotid artery facial motor nucleus skeletal muscle tissue right kidney proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component Golgi transport complex Golgi membrane Golgi apparatus membrane trans-Golgi network membrane cytoplasm cytosol Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport retrograde transport, vesicle recycling within Golgi Golgi vesicle prefusion complex stabilization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25839 102339 Ensembl ENSG00000103051 ENSMUSG00000031753 UniProt Q9H9E3 Q8R1U1 RefSeq (mRNA) NM_001195139 NM_015386 NM_001365426 NM_145818 NM_133973 NM_001310607 RefSeq (protein) NP_001182068 NP_056201 NP_001352355 NP_001297536 NP_598734 Location (UCSC) Chr 16: 70.48 – 70.52 Mb Chr 8: 111.57 – 111.61 Mb PubMed search [3] [4]
Wikidata
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Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM]^[6]

Interactions

COG4 has been shown to interact with COG7,^[7] COG2,^[7] COG1^[7] and COG5.^[7]

Clinical

Mutations in this gene have been associated with Saul-Wilson syndrome.^[8]