COG5

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.^[5][6][7]

COG5
Identifiers
Aliases	COG5, CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
External IDs	OMIM: 606821; MGI: 2145130; HomoloGene: 42221; GeneCards: COG5; OMA:COG5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.3 Start 107,201,555 bp[1] End 107,564,514 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A3 Start 31,704,868 bp[2] End 31,987,629 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon bone marrow cells sural nerve tonsil epithelium of colon skeletal muscle tissue endometrium smooth muscle tissue right auricle of heart Top expressed in genital tubercle tail of embryo spermatocyte ciliary body spermatid right ventricle dentate gyrus of hippocampal formation granule cell thymus neural layer of retina carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytoplasm Golgi transport complex Golgi membrane cytosol Golgi apparatus membrane nucleoplasm trans-Golgi network membrane Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10466 238123 Ensembl ENSG00000164597 ENSG00000284369 ENSMUSG00000035933 UniProt Q9UP83 Q8C0L8 RefSeq (mRNA) NM_001161520 NM_006348 NM_181733 NM_001163126 RefSeq (protein) NP_001154992 NP_006339 NP_859422 NP_001366440 NP_001366441 NP_001366442 NP_001366443 NP_001366444 NP_001366445 NP_001156598 Location (UCSC) Chr 7: 107.2 – 107.56 Mb Chr 12: 31.7 – 31.99 Mb PubMed search [3] [4]
Wikidata
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Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM]^[7]

Interactions

COG5 has been shown to interact with COG7^[8] and COG4.^[8]