COG7

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.^[5][6]

COG7
Identifiers
Aliases	COG7, CDG2E, component of oligomeric golgi complex 7
External IDs	OMIM: 606978; MGI: 2685013; HomoloGene: 33431; GeneCards: COG7; OMA:COG7 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 23,388,493 bp[1] End 23,453,189 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 121,478,586 bp[2] End 121,580,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary canal of the cervix right lobe of thyroid gland left lobe of thyroid gland apex of heart mucosa of transverse colon bronchial epithelial cell olfactory zone of nasal mucosa ectocervix Top expressed in otolith organ utricle Epithelium of choroid plexus supraoptic nucleus decidua lobe of prostate retinal pigment epithelium arcuate nucleus paraventricular nucleus of hypothalamus median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleolus membrane Golgi apparatus Golgi transport complex trans-Golgi network membrane Golgi membrane Biological process protein localization to organelle protein glycosylation endoplasmic reticulum to Golgi vesicle-mediated transport protein transport protein stabilization intracellular protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization protein localization to Golgi apparatus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91949 233824 Ensembl ENSG00000168434 ENSMUSG00000034951 UniProt P83436 Q3UM29 RefSeq (mRNA) NM_153603 NM_001033318 RefSeq (protein) NP_705831 NP_001028490 Location (UCSC) Chr 16: 23.39 – 23.45 Mb Chr 7: 121.48 – 121.58 Mb PubMed search [3] [4]
Wikidata
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For the Adventist denomination, see Church of God (Seventh-Day).

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM]^[6]

Interactions

COG7 has been shown to interact with COG4^[7] and COG5.^[7]