Casein kinase 2, alpha 1

See also: Casein kinase 2

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.^[5][6]

CSNK2A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JWH, 1NA7, 1PJK, 2PVR, 2ZJW, 3AMY, 3AT2, 3AT3, 3AT4, 3AXW, 3BQC, 3C13, 3FWQ, 3H30, 3JUH, 3MB6, 3MB7, 3NGA, 3NSZ, 3OWJ, 3OWK, 3OWL, 3PE1, 3PE2, 3PE4, 3Q04, 3Q9W, 3Q9X, 3Q9Y, 3Q9Z, 3QA0, 3R0T, 3RPS, 3TAX, 3U4U, 3U87, 3U9C, 3W8L, 3WAR, 3WIK, 3WIL, 3WOW, 4DGL, 4FBX, 4GRB, 4GUB, 4GYW, 4GYY, 4GZ3, 4IB5, 4KWP, 4MD7, 4MD8, 4MD9, 4NH1, 4RLL, 4UB7, 4UBA, 5CQU, 5CQW, 5H8G, 5H8B, 5H8E, 5CLP, 5CSH, 5CVH, 5CS6, 5CU6, 5B0X
Identifiers
Aliases	CSNK2A1, Csnk2a1, Csnk2a1-rs4, CK2A1, CKII, CSNK2A3, casein kinase 2 alpha 1, OCNDS, Cka1, Cka2
External IDs	OMIM: 115440; MGI: 88543; HomoloGene: 90874; GeneCards: CSNK2A1; OMA:CSNK2A1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 472,498 bp[1] End 543,835 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 152,068,759 bp[2] End 152,123,772 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone epithelium of colon gingival epithelium Achilles tendon islet of Langerhans rectum stromal cell of endometrium gastrocnemius muscle amniotic fluid Top expressed in genital tubercle tail of embryo lumbar spinal ganglion ventricular zone zygote epiblast blastocyst muscle of thigh ganglionic eminence extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding Hsp90 protein binding protein kinase activity protein N-terminus binding protein serine/threonine kinase activity protein binding ATP binding kinase activity beta-catenin binding protein phosphatase regulator activity ribonucleoprotein complex binding identical protein binding Cellular component NuRD complex cytosol Sin3 complex PcG protein complex nucleus nucleoplasm protein kinase CK2 complex chromatin cytoplasm plasma membrane Biological process chaperone-mediated protein folding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of transcription, DNA-templated positive regulation of protein catabolic process phosphorylation rhythmic process Wnt signaling pathway transcription, DNA-templated positive regulation of Wnt signaling pathway protein phosphorylation positive regulation of cell growth positive regulation of cell population proliferation cell cycle signal transduction apoptotic process regulation of signal transduction by p53 class mediator protein folding phosphatidylcholine biosynthetic process macroautophagy peptidyl-threonine phosphorylation cerebral cortex development response to testosterone protein autophosphorylation liver regeneration regulation of protein localization to plasma membrane regulation of chromosome separation peptidyl-serine phosphorylation negative regulation of ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1457 12995 Ensembl ENSG00000101266 ENSMUSG00000074698 UniProt P68400 Q5U5J2 Q60737 RefSeq (mRNA) NM_001895 NM_177559 NM_177560 NM_001362770 NM_001362771 NM_007788 RefSeq (protein) NP_001886 NP_808227 NP_808228 NP_001349699 NP_001349700 NP_031814 Location (UCSC) Chr 20: 0.47 – 0.54 Mb Chr 2: 152.07 – 152.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.^[7]

Protein Kinase Phosphoryl transfer

Clinical significance

Mutations in CSNK2A1 are causative for Okur-Chung Neurodevelopmental Syndrome (OCNDS).^[8] There are "hot spots" where mutations are more likely to occur, with ~33% of individuals with OCNDS harboring the same genetic change: p.Lys198R.^[9]

Interactions

Casein kinase 2, alpha 1 has been shown to interact with:

• APC,^[10]
• ATF1,^[11]
• ATF2,^[11]
• C-Fos,^[11]
• C-jun,^[11]
• CDC25B,^[12]
• CHEK1,^[13][14]
• CREBBP,^[11]
• CSNK2B,^{[15][16][17][18][19]}
• DDIT3,^[20]
• FGF1,^[21]
• FGF2,^[21]
• HNRPA2B1^[22]
• MAPK14,^[23]
• PIN1,^[24]
• PLEKHO1,^[15]
• PTEN,^[25]
• RELA,^[26]
• TAF1,^[27] and
• UBTF.^[28]