CSNK2A2

See also: Casein kinase 2

Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene.^[5][6]

CSNK2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E3B, 3OFM, 3U87
Identifiers
Aliases	CSNK2A2, CK2A2, CSNK2A1, CK2alpha', casein kinase 2 alpha 2
External IDs	OMIM: 115442; MGI: 88547; HomoloGene: 20444; GeneCards: CSNK2A2; OMA:CSNK2A2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 58,157,907 bp[1] End 58,198,106 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5- D1|8 47.12 cM Start 96,172,724 bp[2] End 96,216,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis right testis skin of leg sperm skin of thigh skin of arm skin of abdomen body of pancreas ganglionic eminence Top expressed in Rostral migratory stream tail of embryo spermatocyte primary oocyte zygote epiblast spermatid genital tubercle lip internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein N-terminus binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol PcG protein complex nucleoplasm chromatin acrosomal vesicle nucleus cytoplasm plasma membrane Biological process regulation of transcription, DNA-templated phosphorylation positive regulation of protein targeting to mitochondrion Wnt signaling pathway transcription, DNA-templated protein phosphorylation regulation of autophagy of mitochondrion cell cycle apoptotic process regulation of signal transduction by p53 class mediator protein folding phosphatidylcholine biosynthetic process spermatogenesis cerebral cortex development liver regeneration regulation of cell cycle macroautophagy regulation of chromosome separation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1459 13000 Ensembl ENSG00000070770 ENSMUSG00000046707 UniProt P19784 O54833 RefSeq (mRNA) NM_001896 NM_009974 RefSeq (protein) NP_001887 NP_034104 Location (UCSC) Chr 16: 58.16 – 58.2 Mb Chr 8: 96.17 – 96.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CSNK2A2 has been shown to interact with over 160 different substrates.^[7]

CSNK2A2 has been shown to interact with:

• Activating transcription factor 2,^[8]
• ATF1,^[8]
• C-Fos,^[8]
• CREB binding protein,^[8]
• CSNK2B,^[9][10][11]
• FGF1,^[12]
• Nucleolin,^[13]
• PIN1,^[14]
• PTEN,^[12][15] and
• RELA.^[16]