CYP20A1

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.^[5]

CYP20A1
Identifiers
Aliases	CYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDs	MGI: 1925201; HomoloGene: 18584; GeneCards: CYP20A1; OMA:CYP20A1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.2 Start 203,238,940 bp[1] End 203,305,611 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 60,382,482 bp[2] End 60,427,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gonad epithelium of colon monocyte islet of Langerhans testicle body of pancreas rectum right adrenal cortex left adrenal gland Top expressed in umbilical cord seminal vesicula calvaria ureter cumulus cell renal corpuscle left lung lobe dermis trigeminal ganglion interventricular septum More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 57404 77951 Ensembl ENSG00000119004 ENSMUSG00000049439 UniProt Q6UW02 Q8BKE6 RefSeq (mRNA) NM_020674 NM_177538 NM_030013 NM_001313721 RefSeq (protein) NP_803882 NP_001358624 NP_001358625 NP_001358626 NP_001358627 NP_001358628 NP_001358629 NP_001358630 NP_001358631 NP_001358632 NP_001358633 NP_001358634 NP_001358635 NP_001300650 NP_084289 Location (UCSC) Chr 2: 203.24 – 203.31 Mb Chr 1: 60.38 – 60.43 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.^[6]

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.