DBF4

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.^[5][6][7]

DBF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F99, 4F9A, 4F9B, 4F9C
Identifiers
Aliases	DBF4, ASK, CHIF, DBF4A, ZDBF1, DBF4 zinc finger
External IDs	OMIM: 604281; MGI: 1351328; HomoloGene: 40892; GeneCards: DBF4; OMA:DBF4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.12 Start 87,876,216 bp[1] End 87,909,553 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A1 Start 8,446,973 bp[2] End 8,472,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad ventricular zone left testis right testis secondary oocyte ganglionic eminence bone marrow sperm bone marrow cells Top expressed in abdominal wall tail of embryo primitive streak mandibular prominence maxillary prominence endothelial cell of lymphatic vessel genital tubercle primary oocyte dermis spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding enzyme activator activity metal ion binding nucleic acid binding protein binding protein kinase binding protein serine/threonine kinase activator activity Cellular component nucleoplasm nucleus nuclear body Dbf4-dependent protein kinase complex Biological process DNA replication cell cycle positive regulation of catalytic activity G1/S transition of mitotic cell cycle positive regulation of DNA replication positive regulation of protein serine/threonine kinase activity positive regulation of nuclear cell cycle DNA replication regulation of cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10926 27214 Ensembl ENSG00000006634 ENSMUSG00000002297 UniProt Q9UBU7 Q9QZ41 RefSeq (mRNA) NM_006716 NM_001318060 NM_001318061 NM_001318062 NM_001190717 NM_013726 RefSeq (protein) NP_001304989 NP_001304990 NP_001304991 NP_006707 NP_001177646 NP_038754 Location (UCSC) Chr 7: 87.88 – 87.91 Mb Chr 5: 8.45 – 8.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

DBF4 has been shown to interact with:

• Cell division cycle 7-related protein kinase,^[5][8][9]
• MCM3,^[8]
• MCM7,^[8]
• ORC2L,^[8] and
• ORC6L.^[8]