AKAP8

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.^[5][6]

AKAP8
Identifiers
Aliases	AKAP8, AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
External IDs	OMIM: 604692; MGI: 1928488; HomoloGene: 4278; GeneCards: AKAP8; OMA:AKAP8 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 15,353,385 bp[1] End 15,379,815 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 32,522,646 bp[2] End 32,540,212 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte right uterine tube Achilles tendon gastrocnemius muscle gastric mucosa left uterine tube spleen body of uterus skin of leg Top expressed in neural layer of retina tail of embryo otic vesicle genital tubercle otic placode ventricular zone cerebellar cortex epiblast cumulus cell saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding zinc ion binding double-stranded DNA binding protein kinase A regulatory subunit binding histone deacetylase binding DEAD/H-box RNA helicase binding protein binding NF-kappaB binding RNA binding Cellular component Golgi apparatus female pronucleus membrane condensed chromosome nucleus mitochondrion nucleoplasm nucleolus nuclear matrix cytoplasm Biological process positive regulation of histone deacetylation mitotic chromosome condensation signal transduction cell cycle G2/M phase transition regulation of transcription, DNA-templated immune system process cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus transcription, DNA-templated protein transport negative regulation of tumor necrosis factor production innate immune response mitotic cell cycle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10270 56399 Ensembl ENSG00000105127 ENSMUSG00000024045 UniProt O43823 Q9DBR0 RefSeq (mRNA) NM_005858 NM_019774 NM_001357760 RefSeq (protein) NP_005849 NP_062748 NP_001344689 Location (UCSC) Chr 19: 15.35 – 15.38 Mb Chr 17: 32.52 – 32.54 Mb PubMed search [3] [4]
Wikidata
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Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.^[6]

Interactions

AKAP8 has been demonstrated to interact with:

• Cyclin D3^[7]
• DDX5,^[8]
• MCM2,^[9]
• MYCBP,^[10] and
• PRKAR2A.^[5][11]