Daf-8

The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.^[1] When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.^[2]

Dwarfin sma
Identifiers
Organism	Caenorhabditis elegans
Symbol	daf-8
Entrez	187612
RefSeq (mRNA)	NM_059920.3
RefSeq (Prot)	NP_492321.1
UniProt	Q21733
Other data
Chromosome	I: 8.58 - 8.59 Mb
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