E2F2

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.^[5][6]

E2F2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N4M
Identifiers
Aliases	E2F2, E2F-2, E2F transcription factor 2
External IDs	OMIM: 600426; MGI: 1096341; HomoloGene: 48264; GeneCards: E2F2; OMA:E2F2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 23,506,438 bp[1] End 23,531,233 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 135,899,705 bp[2] End 135,923,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow bone marrow cells testicle blood gonad mucosa of transverse colon ganglionic eminence ventricular zone monocyte granulocyte Top expressed in blood granulocyte thymus otic vesicle human fetus zygote spleen primary oocyte internal carotid artery hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding protein dimerization activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex nucleoplasm RNA polymerase II transcription regulator complex Biological process regulation of cell cycle cell cycle transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated lens fiber cell apoptotic process intrinsic apoptotic signaling pathway by p53 class mediator transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of sprouting angiogenesis negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1870 242705 Ensembl ENSG00000007968 ENSG00000282899 ENSMUSG00000018983 UniProt Q14209 P56931 RefSeq (mRNA) NM_004091 NM_177733 NM_183301 NM_001305399 RefSeq (protein) NP_004082 NP_001292328 NP_808401 Location (UCSC) Chr 1: 23.51 – 23.53 Mb Chr 4: 135.9 – 135.92 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.^[7]

Interactions

E2F2 has been shown to interact with:

• BRD2,^[8][9]
• RYBP,^[10] and
• RB1.^[11]

See also

• E2F