EIF3C

Eukaryotic translation initiation factor 3 subunit C (eIF3c) is a protein that in humans is encoded by the EIF3C gene.^[5][6]

EIF3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3C, EIF3CL, EIF3S8, eIF3-p110, eukaryotic translation initiation factor 3 subunit C
External IDs	OMIM: 603916; MGI: 1926966; HomoloGene: 2781; GeneCards: EIF3C; OMA:EIF3C - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 28,688,558 bp[1] End 28,735,727 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 69.14 cM|7 F3 Start 126,145,627 bp[2] End 126,165,583 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left testis ganglionic eminence olfactory zone of nasal mucosa right lobe of thyroid gland body of pancreas right testis left lobe of thyroid gland anterior pituitary Brodmann area 9 Top expressed in tail of embryo genital tubercle mandibular prominence maxillary prominence somite endothelial cell of lymphatic vessel Gonadal ridge hair follicle primitive streak dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor binding protein binding translation initiation factor activity RNA binding Cellular component cytoplasm cytosol eukaryotic translation initiation factor 3 complex eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation protein biosynthesis positive regulation of translation positive regulation of mRNA binding formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8663 56347 Ensembl ENSG00000184110 ENSMUSG00000030738 UniProt Q99613 Q8R1B4 RefSeq (mRNA) NM_003752 NM_001037808 NM_001199142 NM_001267574 NM_001286478 NM_146200 RefSeq (protein) NP_001032897 NP_001186071 NP_001254503 NP_001273407 NP_003743 NP_666312 Location (UCSC) Chr 16: 28.69 – 28.74 Mb Chr 7: 126.15 – 126.17 Mb PubMed search [3] [4]
Wikidata
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Interactions

EIF3C has been shown to interact with EIF3G^[7][8] and EIF3A.^[8][9]

See also

• Eukaryotic initiation factor 3 (eIF3)