EIF5B

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.^[5][6][7]

EIF5B
Identifiers
Aliases	EIF5B, IF2, eukaryotic translation initiation factor 5B
External IDs	OMIM: 606086; MGI: 2441772; HomoloGene: 134613; GeneCards: EIF5B; OMA:EIF5B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 99,337,371 bp[1] End 99,401,326 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 38,037,091 bp[2] End 38,094,660 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii oocyte secondary oocyte internal globus pallidus myocardium of left ventricle gingival epithelium pericardium pars reticulata cardia external globus pallidus Top expressed in tail of embryo lens genital tubercle zygote epithelium of lens secondary oocyte parotid gland lacrimal gland primary oocyte epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding metal ion binding GTP binding hydrolase activity translation initiation factor activity RNA binding GTPase activity Cellular component cytosol nucleus cytoplasm Biological process regulation of translational initiation translational initiation protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9669 226982 Ensembl ENSG00000158417 ENSMUSG00000026083 UniProt O60841 Q05D44 RefSeq (mRNA) NM_015904 NM_198303 RefSeq (protein) NP_056988 NP_938045 Location (UCSC) Chr 2: 99.34 – 99.4 Mb Chr 1: 38.04 – 38.09 Mb PubMed search [3] [4]
Wikidata
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Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in bacteria which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.^[7]