EXOC3

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.^[5][6]

EXOC3
Identifiers
Aliases	EXOC3, SEC6, SEC6L1, Sec6p, exocyst complex component 3
External IDs	OMIM: 608186; MGI: 2443972; HomoloGene: 38296; GeneCards: EXOC3; OMA:EXOC3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.33 Start 443,175 bp[1] End 471,937 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 74,317,607 bp[2] End 74,356,851 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon anterior pituitary sural nerve gastric mucosa right uterine tube skin of leg skin of abdomen body of stomach left testis muscle layer of sigmoid colon Top expressed in hand internal carotid artery external carotid artery otolith organ facial motor nucleus utricle dentate gyrus of hippocampal formation granule cell Region I of hippocampus proper renal corpuscle neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding SNARE binding cadherin binding Cellular component cytosol exocyst secretory granule membrane cytoplasm Golgi apparatus growth cone midbody cell projection perinuclear region of cytoplasm presynaptic membrane Biological process protein transport exocyst localization exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11336 211446 Ensembl ENSG00000180104 ENSMUSG00000034152 UniProt O60645 Q6KAR6 RefSeq (mRNA) NM_007277 NM_177333 RefSeq (protein) NP_009208 NP_796307 Location (UCSC) Chr 5: 0.44 – 0.47 Mb Chr 13: 74.32 – 74.36 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.^[6]

Interactions

EXOC3 has been shown to interact with DLG3^[7] and EXOC4.^[7][8]