DLG3

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene.^[5][6] DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

DLG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UM7, 2FE5, 2I1N
Identifiers
Aliases	DLG3, MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3, XLID90
External IDs	OMIM: 300189; MGI: 1888986; HomoloGene: 41157; GeneCards: DLG3; OMA:DLG3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,444,835 bp[1] End 70,505,490 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 99,811,328 bp[2] End 99,862,016 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas buccal mucosa cell ganglionic eminence rectum olfactory zone of nasal mucosa islet of Langerhans middle temporal gyrus pancreatic ductal cell mucosa of transverse colon prefrontal cortex Top expressed in dentate gyrus of hippocampal formation granule cell retinal pigment epithelium superior frontal gyrus hippocampus proper cingulate gyrus piriform cortex olfactory tubercle primary visual cortex Region I of hippocampus proper amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase binding PDZ domain binding protein domain specific binding guanylate kinase activity kinase binding protein C-terminus binding protein binding ionotropic glutamate receptor binding protein phosphatase binding ubiquitin protein ligase binding ligand-gated ion channel activity structural constituent of postsynaptic density Cellular component cytoplasm postsynaptic membrane postsynaptic density cell-cell junction bicellular tight junction growth cone plasma membrane synapse dendritic shaft soma basolateral plasma membrane AMPA glutamate receptor complex ionotropic glutamate receptor complex extracellular space cytosol cell junction neuromuscular junction neuron projection postsynaptic density membrane glutamatergic synapse postsynaptic density, intracellular component Biological process receptor localization to synapse negative regulation of phosphatase activity establishment of planar polarity receptor clustering nervous system development establishment or maintenance of epithelial cell apical/basal polarity negative regulation of cell population proliferation ion transmembrane transport GMP metabolic process GDP metabolic process chemical synaptic transmission MAPK cascade positive regulation of protein tyrosine kinase activity cell-cell adhesion regulation of postsynaptic membrane neurotransmitter receptor levels maintenance of postsynaptic density structure regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1741 53310 Ensembl ENSG00000082458 ENSMUSG00000000881 UniProt Q92796 P70175 RefSeq (mRNA) NM_001166278 NM_020730 NM_021120 NM_001177778 NM_001177779 NM_001177780 NM_001290402 NM_016747 RefSeq (protein) NP_001159750 NP_065781 NP_066943 NP_001171249 NP_001171250 NP_001171251 NP_001277331 NP_058027 Location (UCSC) Chr X: 70.44 – 70.51 Mb Chr X: 99.81 – 99.86 Mb PubMed search [3] [4]
Wikidata
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Interactions

DLG3 has been shown to interact with:

• APC,^[7]
• CRIPT,^[8]
• DLG4,^[9]
• EXOC3,^[10]
• EXOC4,^[10]
• GRIN2A,^[8][11]
• GRIN2B,^{[8][10][11][12]}
• GRIN2C,^[8]
• KCNJ12^[13]
• PTK2B,^[14] and
• SYNGAP1.^[15]