Exosome component 1

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.^[5][6][7]

EXOSC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC1, CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13, Exosome component 1, PCH1F
External IDs	OMIM: 606493; MGI: 1913833; HomoloGene: 9359; GeneCards: EXOSC1; OMA:EXOSC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,435,909 bp[1] End 97,446,017 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 41,910,731 bp[2] End 41,921,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte stromal cell of endometrium body of pancreas monocyte anterior pituitary body of stomach prefrontal cortex gonad mucosa of transverse colon spleen Top expressed in morula tail of embryo embryo embryo otic placode zygote epiblast secondary oocyte primary oocyte genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function exoribonuclease activity protein binding RNA binding Cellular component cytoplasm cytosol nuclear exosome (RNase complex) nucleolus exosome (RNase complex) nucleoplasm nucleus Biological process regulation of mRNA stability exonucleolytic catabolism of deadenylated mRNA rRNA processing RNA phosphodiester bond hydrolysis, exonucleolytic RNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51013 66583 Ensembl ENSG00000171311 ENSMUSG00000034321 UniProt Q9Y3B2 Q9DAA6 RefSeq (mRNA) NM_016046 NM_001318362 NM_001318363 NM_001318364 NM_001318365 NM_001318366 NM_001164561 NM_025644 NM_001320231 NM_001320232 NM_001320233 RefSeq (protein) NP_001305291 NP_001305292 NP_001305293 NP_001305294 NP_001305295 NP_057130 NP_001158033 NP_001307160 NP_001307161 NP_001307162 NP_079920 Location (UCSC) Chr 10: 97.44 – 97.45 Mb Chr 19: 41.91 – 41.92 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.^[7]

Interactions

Exosome component 1 has been shown to interact with:

• Exosome component 5,^[5][8]
• Exosome component 6,^[8] and
• Exosome component 7.^[5][8]