FMNL1

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.^[5][6]

FMNL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YDH
Identifiers
Aliases	FMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDs	OMIM: 604656; MGI: 1888994; HomoloGene: 136798; GeneCards: FMNL1; OMA:FMNL1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,221,444 bp[1] End 45,247,319 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 103,061,933 bp[2] End 103,089,727 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen right lung upper lobe of left lung lymph node bone marrow cells appendix gallbladder Top expressed in granulocyte primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell perirhinal cortex tibiofemoral joint thymus entorhinal cortex lumbar spinal ganglion interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function profilin binding GTPase activating protein binding actin filament binding protein binding actin binding molecular function Cellular component cytoplasm cell projection membrane plasma membrane cell cortex phagocytic vesicle bleb extracellular exosome cytoplasmic vesicle cytosol integral component of membrane Biological process actin filament severing substrate-dependent cell migration cytoskeleton organization regulation of cell shape cellular component organization cortical actin cytoskeleton organization actin cytoskeleton organization cellular process or phenomenon Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 752 57778 Ensembl ENSG00000184922 ENSMUSG00000055805 UniProt O95466 Q9JL26 RefSeq (mRNA) NM_005892 NM_001077698 NM_019679 RefSeq (protein) NP_005883 NP_001071166 NP_062653 NP_001390541 NP_001390542 NP_001390543 NP_001390544 NP_001390545 NP_001390546 NP_001390547 Location (UCSC) Chr 17: 45.22 – 45.25 Mb Chr 11: 103.06 – 103.09 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.^[6]

Interactions

FMNL1 has been shown to interact with Profilin 1,^[7] PFN2^[7] and RAC1.^[7]

See also

• FMNL2
• FMNL3