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FMNL2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

FMNL2
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Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[5][6]

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Expression

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[5] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[7]) is regulated through autoinhibition, and may become activated through Rho proteins.[8] The FMNL2 gene is expressed in multiple human tissues.[9]

Function

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[5]

Clinical significance

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[10]

Clinical studies showed that single nucleotide polymorphisms in the FMNL2 gene are associated with cardio and cerebrovascular risk factors and Alzheimer's disease[11] FMNL2 links vascular disease to increased risk of Alzheimer's disease by regulating the interaction between astrocytes and blood vessels in healthy and Alzheimer's disease brains.[12]

See also

References

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