FMNL3

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.^[5][6]

FMNL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EAH
Identifiers
Aliases	FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3
External IDs	OMIM: 616288; MGI: 109569; HomoloGene: 69101; GeneCards: FMNL3; OMA:FMNL3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,636,499 bp[1] End 49,708,165 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 99,215,106 bp[2] End 99,268,363 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve appendix right coronary artery stromal cell of endometrium lymph node Achilles tendon apex of heart granulocyte left coronary artery right lung Top expressed in primary oocyte granulocyte calvaria internal carotid artery external carotid artery secondary oocyte zygote endocardial cushion semi-lunar valve ankle More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activating protein binding actin binding Cellular component cytoplasm membrane Golgi apparatus cytosol plasma membrane intracellular membrane-bounded organelle Biological process multicellular organism development actin cytoskeleton organization angiogenesis cellular component organization cytoskeleton organization regulation of cell shape cell migration cortical actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91010 22379 Ensembl ENSG00000161791 ENSMUSG00000023008 UniProt Q8IVF7 Q6ZPF4 RefSeq (mRNA) NM_175736 NM_198900 NM_001367835 NM_011711 NM_001310622 NM_001310623 RefSeq (protein) NP_783863 NP_944489 NP_001354764 NP_001297551 NP_001297552 NP_035841 Location (UCSC) Chr 12: 49.64 – 49.71 Mb Chr 15: 99.22 – 99.27 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.^[5] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.^[7] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.^[8]

See also

• FMNL1
• FMNL2