AKAP9

A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene.^[3][4][5] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 ^[6]

AKAP9
Identifiers
Aliases	AKAP9, AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO, A-kinase anchoring protein 9
External IDs	OMIM: 604001; HomoloGene: 17517; GeneCards: AKAP9; OMA:AKAP9 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.2 Start 91,940,840 bp[1] End 92,110,673 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa bronchial epithelial cell sural nerve Achilles tendon Skeletal muscle tissue of rectus abdominis epithelium of colon gastric mucosa right uterine tube Skeletal muscle tissue of biceps brachii mucosa of paranasal sinus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding potassium channel regulator activity protein binding molecular adaptor activity signaling receptor binding protein kinase A regulatory subunit binding DNA binding kinase activity Cellular component cytoplasm cytosol centrosome Golgi apparatus intracellular membrane-bounded organelle voltage-gated potassium channel complex cis-Golgi network microtubule organizing center Golgi stack cytoskeleton dendritic branch synaptic membrane soma glutamatergic synapse extrinsic component of postsynaptic density membrane Biological process positive regulation of peptidyl-serine phosphorylation MAPK cascade G2/M transition of mitotic cell cycle regulation of membrane repolarization regulation of heart rate by cardiac conduction cellular response to cAMP signal transduction positive regulation of potassium ion transmembrane transporter activity microtubule nucleation regulation of ventricular cardiac muscle cell membrane repolarization chemical synaptic transmission response to electrical stimulus negative regulation of adenylate cyclase activity ciliary basal body-plasma membrane docking regulation of cardiac muscle cell action potential involved in regulation of contraction maintenance of centrosome location regulation of G2/M transition of mitotic cell cycle regulation of Golgi organization positive regulation of microtubule polymerization regulation of postsynaptic neurotransmitter receptor activity cardiac conduction phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10142 n/a Ensembl ENSG00000127914 n/a UniProt Q99996 Q6PJH3 n/a RefSeq (mRNA) NM_005751 NM_147166 NM_147171 NM_147185 NM_001379277 n/a RefSeq (protein) NP_005742 NP_671714 NP_001366206 NP_005742.4 NP_671714.1 n/a Location (UCSC) Chr 7: 91.94 – 92.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.^[5]

Interactions

AKAP9 has been shown to interact with:

• CALM2,^[7]
• CALM1,^[7]
• FNBP1,^[8]
• KvLQT1^[9]
• PRKAR2A,^[10][11]
• PKN1,^[10] and
• TRIP10.^[8]